Efflux Pumps.
Jul 1, 2024 11:35:26 GMT
Post by Admin on Jul 1, 2024 11:35:26 GMT
Your infections, those bacteria and fungi, have efflux pumps. Your cells also have these efflux pumps.
These are known as P-glycoprotein and it is a protein found in cell membranes that pumps foreign substances out of cells.
It's also known as multidrug resistance protein 1 (MDR1). It is a defense mechanism so the cells can survive.
“efflux pump”
“Bacterial Efflux”
These are just one reason that antibiotics don’t work very well, just one reason but there are more.
Here we find Doxycycline inducing expression of P-glycoprotein.
www.ncbi.nlm.nih.gov/pmc/articles/PMC127468/#
“Doxycycline Induces Expression of P Glycoprotein in MCF-7 Breast Carcinoma Cells”
“Doxycycline, a drug that has been used for treatment of bacterial infections in cancer patients, can induce functional P-gp expression in cancer cells, resulting in multidrug resistance.”
In contrast Solamargine inhibits these efflux pumps.
pubmed.ncbi.nlm.nih.gov/29720141/
“Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum induces non-selective cytotoxicity and P-glycoprotein inhibition”
“The crude extract and aqueous fraction displayed potent non-selective cytotoxicity and noteworthy P-glycoprotein inhibition. “
MDR or multi drug resistance is a common occurrence that doctors won’t mention because they want your business.
There are a lot of reasons why taking antibiotics is a bad idea not to mention that they don't work very well.
Solamargine gets inside the cells and stops the infection process.
bartonella.freeforums.net/thread/111/immune-system
~d
These are known as P-glycoprotein and it is a protein found in cell membranes that pumps foreign substances out of cells.
It's also known as multidrug resistance protein 1 (MDR1). It is a defense mechanism so the cells can survive.
“efflux pump”
“Bacterial Efflux”
These are just one reason that antibiotics don’t work very well, just one reason but there are more.
Here we find Doxycycline inducing expression of P-glycoprotein.
www.ncbi.nlm.nih.gov/pmc/articles/PMC127468/#
“Doxycycline Induces Expression of P Glycoprotein in MCF-7 Breast Carcinoma Cells”
“Doxycycline, a drug that has been used for treatment of bacterial infections in cancer patients, can induce functional P-gp expression in cancer cells, resulting in multidrug resistance.”
In contrast Solamargine inhibits these efflux pumps.
pubmed.ncbi.nlm.nih.gov/29720141/
“Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum induces non-selective cytotoxicity and P-glycoprotein inhibition”
“The crude extract and aqueous fraction displayed potent non-selective cytotoxicity and noteworthy P-glycoprotein inhibition. “
MDR or multi drug resistance is a common occurrence that doctors won’t mention because they want your business.
There are a lot of reasons why taking antibiotics is a bad idea not to mention that they don't work very well.
Solamargine gets inside the cells and stops the infection process.
bartonella.freeforums.net/thread/111/immune-system
~d