Angiogenesis
Jul 3, 2024 10:58:59 GMT
Post by Admin on Jul 3, 2024 10:58:59 GMT
Bartonella is a cancer causing bacteria and to promote tumor growth it also initiates angiogenisis.
academic.oup.com/femsre/article/36/3/563/634924
“Persistence of Bartonella spp. stealth pathogens: from subclinical infections to vasoproliferative tumor formation”
“Angiogenesis”
www.nature.com/articles/s41467-020-17391-2
“The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis”
www.ncbi.nlm.nih.gov/books/NBK448092/
“Bacillary Angiomatosis”
“Bacillary angiomatosis is also known as epithelioid angiomatosis is an uncommon disease and is a disorder characterized by neovascular proliferation in the skin or the internal organs and presenting as tumor-like masses due to infection with Bartonella henselae or Bartonella quintana. Originally, bacillary angiomatosis was described in HIV patients but is known to occur in other non-HIV immunocompromised states as well as in immunocompetent persons.”
*There a a lot of different kinds of cancer which is free cell proliferation of abnormal cells. Even though Bartonella infection checks all the boxes to qualify as a cancer many will still categorize that as Lymphadenopathy or something traditionally associated with bartonella infection.
It is known that bartonella increases VEGF production.
www.ncbi.nlm.nih.gov/books/NBK6482/
“Vascular Endothelial Growth Factor (VEGF) and Its Role in Non-Endothelial Cells”
“Not only is VEGF a major player in leukemias and lymphomas, it is also highly expressed in a variety of solid malignant tumors,59–61 and correlates with malignant disease progression.62,63 VEGF overexpression in tumors is associated with increased angiogenesis, proliferation and metastasis.64,65 A recently published study showed phosphorylated VEGFR-2 (KDR) expression in numerous solid tumors including three lung carcinomas, three breast carcinomas, three Non Hodgkin's lymphomas, and one melanoma.”
Understanding the disease process is a first step then if the stars align you may be able to find something that inhibits the disease process.
doaj.org/article/a5db414734d14b2b8a257cb4f42fc719
“Evaluation of the Effects of Solamargine Extracted from Solanum Nigrum as an Angiogenesis Inhibitor”
“Findings: Solamargine could significantly decrease the number and length of vessels in a dose-dependent manner. As, the most inhibitory was seen by solamargine 20 µM (number: 5.31 ± 1.80, length: 60.88 ± 7.31 µm) in compare with control group (number: 23.88 ± 2.67, length: 119.39 ± 8.87 µm).Conclusion: The results proposed that solamargine has significant inhibitory effects on the angiogenesis.”
Solamargine is the perfect molecule to counteract what bartonella does to the immune system but it needs to be made bioavailable.
These methods are used to make solamargine bioavalable and are discussed as you read further.
1. Use transdermal delivery to get it in the blood quickly.
2. Use bromelain which is a known drug delivery enhancer.
3. Increase Perforin using fucoidan which also will create a healthy cytokine profile.
Solamargine stops the Bartonella infection process in a dose dependent manner and does this through different mechanisms including re-establishing apoptosis explained here;
bartonella.freeforums.net/thread/111/immune-system
~d
academic.oup.com/femsre/article/36/3/563/634924
“Persistence of Bartonella spp. stealth pathogens: from subclinical infections to vasoproliferative tumor formation”
“Angiogenesis”
www.nature.com/articles/s41467-020-17391-2
“The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis”
www.ncbi.nlm.nih.gov/books/NBK448092/
“Bacillary Angiomatosis”
“Bacillary angiomatosis is also known as epithelioid angiomatosis is an uncommon disease and is a disorder characterized by neovascular proliferation in the skin or the internal organs and presenting as tumor-like masses due to infection with Bartonella henselae or Bartonella quintana. Originally, bacillary angiomatosis was described in HIV patients but is known to occur in other non-HIV immunocompromised states as well as in immunocompetent persons.”
*There a a lot of different kinds of cancer which is free cell proliferation of abnormal cells. Even though Bartonella infection checks all the boxes to qualify as a cancer many will still categorize that as Lymphadenopathy or something traditionally associated with bartonella infection.
It is known that bartonella increases VEGF production.
www.ncbi.nlm.nih.gov/books/NBK6482/
“Vascular Endothelial Growth Factor (VEGF) and Its Role in Non-Endothelial Cells”
“Not only is VEGF a major player in leukemias and lymphomas, it is also highly expressed in a variety of solid malignant tumors,59–61 and correlates with malignant disease progression.62,63 VEGF overexpression in tumors is associated with increased angiogenesis, proliferation and metastasis.64,65 A recently published study showed phosphorylated VEGFR-2 (KDR) expression in numerous solid tumors including three lung carcinomas, three breast carcinomas, three Non Hodgkin's lymphomas, and one melanoma.”
Understanding the disease process is a first step then if the stars align you may be able to find something that inhibits the disease process.
doaj.org/article/a5db414734d14b2b8a257cb4f42fc719
“Evaluation of the Effects of Solamargine Extracted from Solanum Nigrum as an Angiogenesis Inhibitor”
“Findings: Solamargine could significantly decrease the number and length of vessels in a dose-dependent manner. As, the most inhibitory was seen by solamargine 20 µM (number: 5.31 ± 1.80, length: 60.88 ± 7.31 µm) in compare with control group (number: 23.88 ± 2.67, length: 119.39 ± 8.87 µm).Conclusion: The results proposed that solamargine has significant inhibitory effects on the angiogenesis.”
Solamargine is the perfect molecule to counteract what bartonella does to the immune system but it needs to be made bioavailable.
These methods are used to make solamargine bioavalable and are discussed as you read further.
1. Use transdermal delivery to get it in the blood quickly.
2. Use bromelain which is a known drug delivery enhancer.
3. Increase Perforin using fucoidan which also will create a healthy cytokine profile.
Solamargine stops the Bartonella infection process in a dose dependent manner and does this through different mechanisms including re-establishing apoptosis explained here;
bartonella.freeforums.net/thread/111/immune-system
~d