Perforin
Aug 4, 2024 14:00:25 GMT
Post by Admin on Aug 4, 2024 14:00:25 GMT
Bartonella interferes with Perforin.
elifesciences.org/articles/06508
“Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria”
journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.0020115
(Bartonella Henselae)
“A Translocated Bacterial Protein Protects Vascular Endothelial Cells from Apoptosis”
“To asses if the here identified anti-apoptotic activity of Bh BepA might be able to protect the cellular habitat of Bh during the infection process, we used a co-culture system of HUVECs with human CTLs. CTLs execute cell-mediated immunity, an immune mechanism probably involved in the elimination of Bh infection [9,12,47]. Cell-mediated immunity particularly serves as a defense mechanism against microbes that survive and replicate inside infected host cells. Upon recognition of MHC class I–displaying microbial peptides, CTLs are activated to kill their target cells by the release of perforin and granzymes [31,48]. Perforin forms pores in the target cell membrane and assists the delivery of pan-caspase-activating granzymes into the cytoplasm of the target cell [44,49,50]. In our study, we used a CTL clone that is activated in an MHC class I–restricted manner by extracellular loading of HLA-A2-positive HUVECs with an HLA-A2-specific peptide (SMCY). Such activated CTLs kill their target cells in a perforin-dependent manner [32], primarily by triggering granzyme-dependent apoptosis [50,51]. Bh BepA–expressing strains indeed inhibited CTL-triggered EC apoptosis”
“Bh BepA–expressing strains indeed inhibited CTL-triggered EC apoptosis, indicating that the biological function of Bh BepA expression in vivo might be to protect the integrity of its colonized cellular niche. “
NK cells release Perforin and Granzyme when activated . Perforin allows an infected cells membrane to be perforated while granzyme initiates intrinsic pathway apoptosis.
“Perforin Granzyme Pathway”
These perforations , pores, that Perforin creates in infected cells should not only allow Granzyme but also other cytotoxic cytokines to enter the cells thereby increasing the potential for apoptosis and death of infected cells.
www.ncbi.nlm.nih.gov/pmc/articles/PMC6888040/
“Activation of NK cells in male cancer survivors by fucoidan extracted from Cladosiphon okamuranus”
pubmed.ncbi.nlm.nih.gov/17054048/
“The role of NK cells in antitumor activity of dietary fucoidan from Undaria pinnatifida sporophylls (Mekabu)”
“Thus, these findings suggested that Mekabu fucoidan mediates tumor destruction through Th1 cell and NK cell responses.”
www.ncbi.nlm.nih.gov/pmc/articles/PMC4439970/
“Perforin: an important player in immune response”
“Perforin is a glycoprotein responsible for pore formation in cell membranes of target cells. Perforin is able to polymerize and form a channel in target cell membrane.
Many research groups focus on the role of perforin in various diseases, immune response to bacterial and viral infections, immune surveillance and immunopathology.
~Natural killer (NK) cells and CD8-positive T-cells are the main source of perforin.”
Fucoidan is also an ingredient in many combination therapies recently developed.
People think that bartonella is just an infection but there are two parts to it.
*The first part is the infection and that itself is hard to get rid of because of the different defense mechanisms bartonella uses, antibiotics don’t clear the infection completely.
*The second part is the cancer that bartonella causes and once established that cancer will proceed on it’s own.
Increasing the level of Performin will partly overwhelm the infected cells ability to deal with it and it will help deal with the abnormal cells that the infection creates.
Fucoidan as an adjunct therapy will add to the effectiveness and bioavailability of other immunotherapy treatments.
www.iherb.com/pr/life-extension-optimized-fucoidan-with-maritech-926-60-vegetarian-capsules/37817
Adding this to an already established Immunotherapy will increase effectiveness.
Or this one would also work;
www.iherb.com/pr/nature-s-way-bladderwrack-580-mg-100-vegan-capsules/1844
Bartonella creates immune checkpoints and using Solamargine blocks these checkpoints or counteracts them so the immune system will attack Bartonella. Adding Fucoidan makes this process more effective by activating NK cells.
www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.733246/full
“Fucoidan-Supplemented Diet Potentiates Immune Checkpoint Blockage by Enhancing Antitumor Immunity”
“In addition to inducing NK activation, ample studies have established that fucoidan treatments alone promote the maturation of dendritic cells (DCs) through binding to toll-like receptors (TLR) and scavenger receptors-“
www.ncbi.nlm.nih.gov/pmc/articles/PMC10421178/
"Novel Fucoidan Pharmaceutical Formulations and Their Potential Application in Oncology"
"Due to its low toxicity, biocompatibility and biodegradability, fucoidan plays an important role as a drug carrier for the formulation of various drug delivery systems, especially as a biopolymer with anticancer activity"
Using Solamargine and Fucoidan together in a protocol is a powerful anti bartonella treatment.
Effective treatment of the lyme complex is not hard to do but you need to understand some things about the immune system to do it;
bartonella.freeforums.net/thread/138/cell-exhaustion-fixed
~d
elifesciences.org/articles/06508
“Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria”
journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.0020115
(Bartonella Henselae)
“A Translocated Bacterial Protein Protects Vascular Endothelial Cells from Apoptosis”
“To asses if the here identified anti-apoptotic activity of Bh BepA might be able to protect the cellular habitat of Bh during the infection process, we used a co-culture system of HUVECs with human CTLs. CTLs execute cell-mediated immunity, an immune mechanism probably involved in the elimination of Bh infection [9,12,47]. Cell-mediated immunity particularly serves as a defense mechanism against microbes that survive and replicate inside infected host cells. Upon recognition of MHC class I–displaying microbial peptides, CTLs are activated to kill their target cells by the release of perforin and granzymes [31,48]. Perforin forms pores in the target cell membrane and assists the delivery of pan-caspase-activating granzymes into the cytoplasm of the target cell [44,49,50]. In our study, we used a CTL clone that is activated in an MHC class I–restricted manner by extracellular loading of HLA-A2-positive HUVECs with an HLA-A2-specific peptide (SMCY). Such activated CTLs kill their target cells in a perforin-dependent manner [32], primarily by triggering granzyme-dependent apoptosis [50,51]. Bh BepA–expressing strains indeed inhibited CTL-triggered EC apoptosis”
“Bh BepA–expressing strains indeed inhibited CTL-triggered EC apoptosis, indicating that the biological function of Bh BepA expression in vivo might be to protect the integrity of its colonized cellular niche. “
NK cells release Perforin and Granzyme when activated . Perforin allows an infected cells membrane to be perforated while granzyme initiates intrinsic pathway apoptosis.
“Perforin Granzyme Pathway”
These perforations , pores, that Perforin creates in infected cells should not only allow Granzyme but also other cytotoxic cytokines to enter the cells thereby increasing the potential for apoptosis and death of infected cells.
www.ncbi.nlm.nih.gov/pmc/articles/PMC6888040/
“Activation of NK cells in male cancer survivors by fucoidan extracted from Cladosiphon okamuranus”
pubmed.ncbi.nlm.nih.gov/17054048/
“The role of NK cells in antitumor activity of dietary fucoidan from Undaria pinnatifida sporophylls (Mekabu)”
“Thus, these findings suggested that Mekabu fucoidan mediates tumor destruction through Th1 cell and NK cell responses.”
www.ncbi.nlm.nih.gov/pmc/articles/PMC4439970/
“Perforin: an important player in immune response”
“Perforin is a glycoprotein responsible for pore formation in cell membranes of target cells. Perforin is able to polymerize and form a channel in target cell membrane.
Many research groups focus on the role of perforin in various diseases, immune response to bacterial and viral infections, immune surveillance and immunopathology.
~Natural killer (NK) cells and CD8-positive T-cells are the main source of perforin.”
Fucoidan is also an ingredient in many combination therapies recently developed.
People think that bartonella is just an infection but there are two parts to it.
*The first part is the infection and that itself is hard to get rid of because of the different defense mechanisms bartonella uses, antibiotics don’t clear the infection completely.
*The second part is the cancer that bartonella causes and once established that cancer will proceed on it’s own.
Increasing the level of Performin will partly overwhelm the infected cells ability to deal with it and it will help deal with the abnormal cells that the infection creates.
Fucoidan as an adjunct therapy will add to the effectiveness and bioavailability of other immunotherapy treatments.
www.iherb.com/pr/life-extension-optimized-fucoidan-with-maritech-926-60-vegetarian-capsules/37817
Adding this to an already established Immunotherapy will increase effectiveness.
Or this one would also work;
www.iherb.com/pr/nature-s-way-bladderwrack-580-mg-100-vegan-capsules/1844
Bartonella creates immune checkpoints and using Solamargine blocks these checkpoints or counteracts them so the immune system will attack Bartonella. Adding Fucoidan makes this process more effective by activating NK cells.
www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.733246/full
“Fucoidan-Supplemented Diet Potentiates Immune Checkpoint Blockage by Enhancing Antitumor Immunity”
“In addition to inducing NK activation, ample studies have established that fucoidan treatments alone promote the maturation of dendritic cells (DCs) through binding to toll-like receptors (TLR) and scavenger receptors-“
www.ncbi.nlm.nih.gov/pmc/articles/PMC10421178/
"Novel Fucoidan Pharmaceutical Formulations and Their Potential Application in Oncology"
"Due to its low toxicity, biocompatibility and biodegradability, fucoidan plays an important role as a drug carrier for the formulation of various drug delivery systems, especially as a biopolymer with anticancer activity"
Using Solamargine and Fucoidan together in a protocol is a powerful anti bartonella treatment.
Effective treatment of the lyme complex is not hard to do but you need to understand some things about the immune system to do it;
bartonella.freeforums.net/thread/138/cell-exhaustion-fixed
~d