Mesenchymal Stem Cells
Mar 20, 2024 9:36:36 GMT
Post by Admin on Mar 20, 2024 9:36:36 GMT
When applying the Solamargine salve to the Shin Bones and Thigh Bones in the front of your legs to gain penetration to the Bone Marrow then Mesenchymal stem cells become activated.
www.ncbi.nlm.nih.gov/pmc/articles/PMC7746825/
“TNFR2 Is a Crucial Hub Controlling Mesenchymal Stem Cell Biological and Functional Properties”
*We know that Bartonella shuts down TNF/TNFR pathways to achieve persistent infection.
bartonella.freeforums.net/thread/17/tnf
*We know that restoring those pathways results is activating the immune system against Bartonella.
“Mesenchymal stem cells (MSCs) have drawn lots of attention as gold standard stem cells in fundamental and clinical researches during the last 20 years. Due to their tissue and vascular repair capacities, MSCs have been used to treat a variety of degenerative disorders. Moreover, MSCs are able to modulate immune cells’ functions, particularly T cells while inducing regulatory T cells (iTregs). “
“Hampering in TNFR2 signaling resulted in reduced MSC colony-forming units and proliferation rate and diminished the expression of all MSC characteristic markers such as stem cell antigen-1 (Sca1), CD90, CD105, CD44, and CD73. TNFR2 KO-MSCs produced more pro-inflammatory cytokines like TNFα, IFNγ, and IL-6 and less anti-inflammatory mediators such as IL-10, TGFβ, and NO and induced Tregs with less suppressive effect. Furthermore, the TNFR2 blockade remarkably decreased MSC regenerative functions such as wound healing, complex tube formation, and endothelial pro-angiogenic support. Therefore, our results reveal the TNFα–TNFR2 axis as a crucial regulator of MSC immunological and regenerative functions.”
Since we know that Bartonella interferes with those pathways and we have a tool that restores those pathways it is a simple approach to solving the bartonella problem.
pubmed.ncbi.nlm.nih.gov/15336528/
“Action of solamargine on TNFs and cisplatin-resistant human lung cancer cells”
“SM elevated the expressions of TNF-R1 and -R2 and overcame the resistance of A549 cells to TNF-alpha and -beta.”
cancerci.biomedcentral.com/articles/10.1186/s12935-016-0287-4
“Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway”
“Solamargine treatment up-regulated the expression of tumor necrosis factor receptors (TNF-R1 and TNF-R2) “
"Mesenchymal stem cells in cell and gene therapy"
When you apply it as part of a protocol and your immune system jumps to life then you are about to deal with a backlog of infection that your immune system has been neglecting.
bartonella.freeforums.net/thread/72/bone-marrow
~d
www.ncbi.nlm.nih.gov/pmc/articles/PMC7746825/
“TNFR2 Is a Crucial Hub Controlling Mesenchymal Stem Cell Biological and Functional Properties”
*We know that Bartonella shuts down TNF/TNFR pathways to achieve persistent infection.
bartonella.freeforums.net/thread/17/tnf
*We know that restoring those pathways results is activating the immune system against Bartonella.
“Mesenchymal stem cells (MSCs) have drawn lots of attention as gold standard stem cells in fundamental and clinical researches during the last 20 years. Due to their tissue and vascular repair capacities, MSCs have been used to treat a variety of degenerative disorders. Moreover, MSCs are able to modulate immune cells’ functions, particularly T cells while inducing regulatory T cells (iTregs). “
“Hampering in TNFR2 signaling resulted in reduced MSC colony-forming units and proliferation rate and diminished the expression of all MSC characteristic markers such as stem cell antigen-1 (Sca1), CD90, CD105, CD44, and CD73. TNFR2 KO-MSCs produced more pro-inflammatory cytokines like TNFα, IFNγ, and IL-6 and less anti-inflammatory mediators such as IL-10, TGFβ, and NO and induced Tregs with less suppressive effect. Furthermore, the TNFR2 blockade remarkably decreased MSC regenerative functions such as wound healing, complex tube formation, and endothelial pro-angiogenic support. Therefore, our results reveal the TNFα–TNFR2 axis as a crucial regulator of MSC immunological and regenerative functions.”
Since we know that Bartonella interferes with those pathways and we have a tool that restores those pathways it is a simple approach to solving the bartonella problem.
pubmed.ncbi.nlm.nih.gov/15336528/
“Action of solamargine on TNFs and cisplatin-resistant human lung cancer cells”
“SM elevated the expressions of TNF-R1 and -R2 and overcame the resistance of A549 cells to TNF-alpha and -beta.”
cancerci.biomedcentral.com/articles/10.1186/s12935-016-0287-4
“Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway”
“Solamargine treatment up-regulated the expression of tumor necrosis factor receptors (TNF-R1 and TNF-R2) “
"Mesenchymal stem cells in cell and gene therapy"
When you apply it as part of a protocol and your immune system jumps to life then you are about to deal with a backlog of infection that your immune system has been neglecting.
bartonella.freeforums.net/thread/72/bone-marrow
~d