Bartonella Henselae Inhibits Cellular Apoptotic Regulators
Mar 27, 2024 14:02:33 GMT
Post by Admin on Mar 27, 2024 14:02:33 GMT
When considering the Bartonella infection problem the current thought process is to find some magic antibiotic. This is because current antibiotics don’t kill Bartonella due to it’s defense mechanisms. You also find misinformation about their efficacy saying they work great and this misinformation is from people posing in lab coats who haven’t taken any time to actually understand Bartonella’s infection process.
Let’s talk about the Immune system and apoptosis.
pubmed.ncbi.nlm.nih.gov/9374039/#:
“Apoptosis is important in the immune system, and plays significant roles in the control of the immune response, the deletion of immune cells recognising self-antigens, and cytotoxic killing. Some of the molecular regulators of these processes, such as CD95 and bcl-2 family proteins are the subjects of intense research.”
scholarworks.gsu.edu/cgi/viewcontent.cgi?article=1068&context=biology_diss&fbclid=IwAR3eqh6MOiLTeRON_nTA98_WnGFWzuePGyxWHWyRh-CNsDHmatzfRaYFz18_aem_AWqCIGqKM6jy6g4diN5oaYZVjlwmNLZLWIneaHZIrRP0NqzO4LZDpEl-jNpYTti2oYrmg24tVQK6TPp7H6i_TDbP
“Bartonella Henselae Inhibits Cellular Apoptotic Regulators to Ensure Survival”
I covered the TNF ligands and TNFR-1 and TNFR-2 and how they are important to return your immune system to a functional state. Those are PRO- apoptotic pathways.
bartonella.freeforums.net/thread/79/mesenchymal-stem-cells
Let’s talk about the inhibitory apoptotic pathways Bcl-2 and Bcl-xL.
"What is Apoptosis?"
Bcl-2 is a cellular protein that inhibits apoptosis.
I talked about how Solamargine restores apoptosis in the TNF/TNFR pathways.
bartonella.freeforums.net/thread/79/mesenchymal-stem-cells
Here we find Solamargine downregulating the apoptosis inhibitors Bcl-2 and Bcl-xL.
pubmed.ncbi.nlm.nih.gov/15527763/
“SM treatment increased the binding activities of TNF-alpha and TNF-beta to the lung cancers, and the intrinsic TNFs-resistant cancer cells became susceptible to TNF-alpha and -beta. In addition, SM caused release of cytochrome c, downregulation of anti-apoptotic Bcl-2 and Bcl-xL, increase of caspase-3 activity, and DNA fragmentation.”
Here it is shown that Bartonella alters the ratio of Bax and Bcl-2.
pubmed.ncbi.nlm.nih.gov/16926411/
“B. henselae-mediated inhibition of apoptosis, as indicated by gene expression of Bax and Bcl-2”
www.ncbi.nlm.nih.gov/pmc/articles/PMC3255967/
"The mitogenic stimulus was accompanied by a potent antiapoptotic effect via a strong increase in the ratio of Bcl-2 to Bax, and both cell proliferation and inhibition of apoptosis were dependent on IL-8, thus confirming published work that IL-8 heavily promotes angiogenesis by stimulating endothelial cell proliferation and inhibiting apoptosis via pathways including the aforementioned ones "
Not only does Solamargine affect pro-apoptotic regulators by turning them back on, it also shuts down the gene expression of anti-apoptotic regulators of the Bcl-2 family.
This combination is what is needed to treat bartonella infection because it is an immune system disease.
bartonella.freeforums.net/thread/17/tnf
~d
Let’s talk about the Immune system and apoptosis.
pubmed.ncbi.nlm.nih.gov/9374039/#:
“Apoptosis is important in the immune system, and plays significant roles in the control of the immune response, the deletion of immune cells recognising self-antigens, and cytotoxic killing. Some of the molecular regulators of these processes, such as CD95 and bcl-2 family proteins are the subjects of intense research.”
scholarworks.gsu.edu/cgi/viewcontent.cgi?article=1068&context=biology_diss&fbclid=IwAR3eqh6MOiLTeRON_nTA98_WnGFWzuePGyxWHWyRh-CNsDHmatzfRaYFz18_aem_AWqCIGqKM6jy6g4diN5oaYZVjlwmNLZLWIneaHZIrRP0NqzO4LZDpEl-jNpYTti2oYrmg24tVQK6TPp7H6i_TDbP
“Bartonella Henselae Inhibits Cellular Apoptotic Regulators to Ensure Survival”
I covered the TNF ligands and TNFR-1 and TNFR-2 and how they are important to return your immune system to a functional state. Those are PRO- apoptotic pathways.
bartonella.freeforums.net/thread/79/mesenchymal-stem-cells
Let’s talk about the inhibitory apoptotic pathways Bcl-2 and Bcl-xL.
"What is Apoptosis?"
Bcl-2 is a cellular protein that inhibits apoptosis.
I talked about how Solamargine restores apoptosis in the TNF/TNFR pathways.
bartonella.freeforums.net/thread/79/mesenchymal-stem-cells
Here we find Solamargine downregulating the apoptosis inhibitors Bcl-2 and Bcl-xL.
pubmed.ncbi.nlm.nih.gov/15527763/
“SM treatment increased the binding activities of TNF-alpha and TNF-beta to the lung cancers, and the intrinsic TNFs-resistant cancer cells became susceptible to TNF-alpha and -beta. In addition, SM caused release of cytochrome c, downregulation of anti-apoptotic Bcl-2 and Bcl-xL, increase of caspase-3 activity, and DNA fragmentation.”
Here it is shown that Bartonella alters the ratio of Bax and Bcl-2.
pubmed.ncbi.nlm.nih.gov/16926411/
“B. henselae-mediated inhibition of apoptosis, as indicated by gene expression of Bax and Bcl-2”
www.ncbi.nlm.nih.gov/pmc/articles/PMC3255967/
"The mitogenic stimulus was accompanied by a potent antiapoptotic effect via a strong increase in the ratio of Bcl-2 to Bax, and both cell proliferation and inhibition of apoptosis were dependent on IL-8, thus confirming published work that IL-8 heavily promotes angiogenesis by stimulating endothelial cell proliferation and inhibiting apoptosis via pathways including the aforementioned ones "
Not only does Solamargine affect pro-apoptotic regulators by turning them back on, it also shuts down the gene expression of anti-apoptotic regulators of the Bcl-2 family.
This combination is what is needed to treat bartonella infection because it is an immune system disease.
bartonella.freeforums.net/thread/17/tnf
~d